S – He said to me, ‘Go, because I will send you far away to the Gentiles.’ ” 

²² They listened to him up to this point. Then they raised their voices, shouting, “Wipe this man off the face of the earth! He should not be allowed to live

Acts 22:21–22 CSB

O – When Paul mentioned his commission to preach to the Gentiles, the mob was moved to instant rage and violence. Preaching to Gentiles could not have caused such a response because the religious authorities of Israel had preached to Gentiles (cf. Matt. 23:15). Paul’s message that infuriated the mob was that Jews and Gentiles were equal without the Law of Moses (cf. Eph. 2:11–22; 3:2–6; Gal. 3:28).

This response is important to the argument of the Book of Acts. It indicates the Jews in Jerusalem had irrevocably refused the gospel of Jesus Christ and had sealed their fate. Less than 20 years later in a.d. 70 the city of Jerusalem became rubble and ruin. (cf. Matt. 24:1–2; 21:41; 22:7)

“Acts,” in The Bible Knowledge Commentary: An Exposition of the Scriptures

A – There are people today who refuse the gospel of Christ.  There are consequences to rejecting God’s love.  The irony is the rejection in Jerusalem actually pushed the gospel to be preached throughout the world and be accepted by so many more.  

R – Lord, help me to invite you into all of the areas of my life.  By closing you off from any area means I am not totally surrendered to you.  I surrender it all to you.