S – When Jesus had said this, he was troubled in his spirit and testified, “Truly I tell you, one of you will betray me.

John 13:21 CSB

O – Commentary: 

Jesus was troubled in spirit. The word “troubled” is etarachthē (“stirred or agitated”), the same word used of Jesus in 11:33; 12:27 (also used by Jesus in 14:1, 27). Being human, Jesus was troubled over Judas’ soon betrayal of His love and friendship. Being divine, Jesus knew in advance that it would happen. Jesus sensed the spiritual hardness and deadness which sin had produced in Judas. The word testified and the formula I tell you the truth stress the solemn announcement of Jesus’ words.

“John,” in The Bible Knowledge Commentary: An Exposition of the Scriptures

A – Even though Jesus knew it was part of God’s plan, the betrayal and loss of relationship with someone he loved still hurt.  As we interact with others, there will be pain and challenge.  God is all-knowing -past, present and future.  He will use the pain for His good.  We must continue to love and value others through the pain.

R – Heavenly Father, thank you for another day with you and others today.  We invite your Holy Spirit to lead us in our thoughts, words and actions.  As we encounter challenges, let us have a heart for you and others like Jesus did.  Give us strength and peace as we navigate those relationships.